Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results
Cantin Baron, Sarah Cherkaoui, Sandra Therrien-Laperriere, Yann Ilboudo, Raphaël Poujol, Pamela Mehanna, Melanie E. Garrett, Marilyn J. Telen, Allison E. Ashley‐Koch, Pablo Bartolucci, John David Rioux, Guillaume Lettre, Christine Des Rosiers, Matthieu Ruiz, Julie Hussin
This paper introduces the shortest reactional distance (SRD) metric to improve the biological interpretation of metabolite genome-wide association study (mGWAS) results by linking genes to metabolites based on metabolic pathway knowledge.
iScience · Nov 14, 2023Peer-reviewedSystems Biology