Melanie E. Garrett

This study identifies a BACH2-NRF2 axis regulating fetal hemoglobin activation through genetic and functional analyses in a large multi-ancestry cohort.

This paper performs a local ancestry-aware GWAS on SCD cohorts to identify novel genetic loci associated with eGFR, uncovering regions linked to inflammation, ECM integrity, and other pathways relevant to SCD nephropathy.

This study identifies shared and distinct genetic factors underlying suicidality phenotypes using GWAS and structural equation modelling.

This study conducts the first genome-wide association analysis of trichotillomania and finds no significant common variants but detects higher polygenic risk and copy number variants associated with neuropsychiatric disorders.

This study compares the transcriptomic landscapes of Alzheimer's disease, Dementia with Lewy bodies, and Parkinson's disease using single-nucleus RNA sequencing to identify shared and distinct molecular features.

The paper uses genomic structural equation modeling to identify latent genetic factors underlying cortical surface area and thickness, finding genetic correlations with psychiatric disorders.

This paper introduces the shortest reactional distance (SRD) metric to improve the biological interpretation of metabolite genome-wide association study (mGWAS) results by linking genes to metabolites based on metabolic pathway knowledge.

This study uses single-nucleus multi-omics data to identify cis and trans regulatory networks and their target genes in Alzheimer's disease brains.

The paper evaluates polygenic trait scores for hematological traits in sickle cell disease patients, finding limited predictive power for complications but significant associations for fetal hemoglobin.

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

The paper identifies sex-dependent glial-specific chromatin accessibility changes in late-onset Alzheimer's disease brains using ATAC-seq and links them to LOAD-GWAS regions.

The paper identifies cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation and links these to regulatory mechanisms of neuropsychiatric disorder risk variants.

This study identifies 59 sentinel variants and two novel genes associated with telomere length using whole genome sequences from 109,122 trans-ethnic individuals.

The paper uses Mendelian randomization to confirm a causal link between L-glutamine levels and reduced painful crises in sickle cell disease, while finding no significant causal relationships for other metabolites.

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

This study identifies ten novel methylation loci associated with PTSD through a meta-analysis of 1,896 cases and controls across ten cohorts, highlighting the AHRR locus and its link to kynurenine levels.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

The paper conducts a GWAS of hippocampal subfield volumes in PTSD cases and trauma-exposed controls, identifying genetic associations and gene-environment interactions.

The paper evaluates chromatin accessibility in prefrontal cortex samples from schizophrenia cases and controls, finding high heritability enrichment in open chromatin regions but no differential accessibility between groups.