New three-dimensional preclinical models to understand and treat liver cancers activated for the β-catenin pathway
Vanessa Bou Malham, Fanny Léandre, Akila Hamimi, Isabelle Lagoutte, Sandrine Bouchet, Angélique Gougèlet, Sabine Colnot, Christèle Desbois‐Mouthon
This paper develops 3D preclinical models of β-catenin-driven liver cancers using organoids and tumouroids from mouse models, showing they preserve tissue features and respond to WNTinib treatment.
bioRxiv · Apr 3, 2026 · PreprintCell Biology