Angélique Gougèlet

New three-dimensional preclinical models to understand and treat liver cancers activated for the β-catenin pathway

This paper develops 3D preclinical models of β-catenin-driven liver cancers using organoids and tumouroids from mouse models, showing they preserve tissue features and respond to WNTinib treatment.

Hepatocyte expression of fetal insulin receptor isoform contributes to the promotion of liver cancer through non-cell autonomous mechanisms

This study shows that hepatocyte expression of fetal insulin receptor isoform INSR-A promotes liver cancer through non-cell autonomous mechanisms by increasing inflammation and enabling preneoplastic cell proliferation.