Glucocorticoids desensitize hypothalamic CRH neurons to norepinephrine and somatic stress activation via rapid nitrosylation-dependent regulation of α1 adrenoreceptor trafficking
Grant L. Weiss, Laura M. Harrison, Zhiying Jiang, Alyssa M. Nielsen, Maximillian S Feygin, Sandy Nguyen, Parker S Tirrell, Jeffrey G. Tasker
This study shows glucocorticoids rapidly desensitize CRH neurons to norepinephrine by regulating α1 adrenoreceptor trafficking through nitrosylation and endocytosis.
bioRxiv · Jul 29, 2024 · PreprintNeuroscience