Grant L. Weiss

Network and behavioral signatures of postpartum behavioral deficits improve with a neurosteroid-based treatment

This study shows that neurosteroid-based treatment improves network and behavioral deficits in postpartum mice by restoring theta oscillations and maternal behavior.

Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles

The paper shows that specific BLA neurons are recruited by oscillatory states to drive valence-related behaviors.

A network approach with motion sequencing reveals hidden patterns of repetitive behavior in a pre-clinical model of epilepsy

This study uses Motion Sequencing combined with a novel analysis pipeline to identify repetitive behaviors in epileptic mice and shows that carbamazepine partially rescues these behaviors.

An Amygdalar Oscillatory Switch Governs Valence Assignment

This study identifies a PV-driven oscillatory switch in the amygdala that governs valence assignment through noradrenergic modulation.

Early life stress impairs VTA coordination of BLA network and behavioral states

This study shows that early life stress impairs VTA coordination of BLA network and behavioral states by weakening dopamine signaling between VTA and BLA, leading to increased social avoidance.

Early life stress influences epilepsy outcomes in mice

This study shows that early life stress affects epilepsy outcomes in mice, with sex-dependent effects on seizure susceptibility and mortality.

Glucocorticoids desensitize hypothalamic CRH neurons to norepinephrine and somatic stress activation via rapid nitrosylation-dependent regulation of α1 adrenoreceptor trafficking

This study shows glucocorticoids rapidly desensitize CRH neurons to norepinephrine by regulating α1 adrenoreceptor trafficking through nitrosylation and endocytosis.

Sex-dependent effects of early life stress on network and behavioral states.

This study investigates sex-dependent effects of early life stress on network and behavioral states in mice, finding sex-specific alterations in physiology and network activity linked to stress reactivity.

Basolateral amygdala parvalbumin interneurons coordinate oscillations to drive reward behaviors

This study shows that parvalbumin interneurons in the basolateral amygdala coordinate oscillations that drive reward behaviors and are necessary for reward value processing.

Experience-dependent information routing through the basolateral amygdala

This study shows that prior positive or negative experiences alter the activity of specific BLA neurons, affecting valence processing by biasing information routing.

Impaired endogenous neurosteroid signaling contributes to behavioral deficits associated with chronic stress

This study shows chronic stress impairs endogenous neurosteroid signaling in the BLA, leading to behavioral deficits, and suggests targeting neurosteroidogenesis could be a new treatment for mood disorders.

Hypothalamic-pituitary-adrenal axis dysfunction worsens epilepsy outcomes and increases SUDEP risk

This study shows that HPA axis dysfunction in a mouse model increases SUDEP risk and worsens epilepsy outcomes, with potential implications for psychiatric comorbidities.

Allopregnanolone mediates affective switching through modulation of oscillatory states in the basolateral amygdala

This study shows allopregnanolone modulates oscillatory states in the basolateral amygdala through delta-containing GABAA receptors, contributing to antidepressant effects.

Acute Stress Desensitizes Hypothalamic CRH Neurons to Norepinephrine and Physiological Stress

The paper shows that acute stress reduces the response of CRH neurons to norepinephrine and physiological stress through glucocorticoid-mediated adrenoreceptor desensitization.