Heat-shock pathway activation by TRC051384 protects spiral ganglion neurons from noise-induced hearing loss
Jintao Yu, Miguel A. Ramirez, Yizhi Wang, Seby Louis Edassery, Maxwell Edwin Shramuk, SangEun Yeom, Casey Jiaxi Li, Yuvraj Joshi, Mary Ann Cheatham, Mark Allen Rutherford, Leah J. Welty, Jeffrey N. Savas
TRC051384, an Hsf1 activator, protects spiral ganglion neurons from noise-induced hearing loss by restoring proteasome function and preserving synapse density.
JCI Insight · Aug 25, 2026Peer-reviewedNeuroscience