Mark Allen Rutherford

TRC051384, an Hsf1 activator, protects spiral ganglion neurons from noise-induced hearing loss by restoring proteasome function and preserving synapse density.

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

The paper presents a large annotated dataset of cochlear hair cells for machine learning applications in hearing research.

This study shows that female GluA3-KO mice develop early hearing loss and afferent swellings when exposed to ambient sound, suggesting sex-dependent vulnerability to AMPAR-mediated excitotoxicity.

This study shows that GluA3 is essential for the proper assembly of AMPAR subunits and presynaptic ribbon morphology in cochlear synapses, leading to hearing loss in mice.