Yizhi Wang

BLIS-XL-MS enables proteome-wide analysis of structural remodeling in brain tissue by combining experimental and computational methods to study protein conformational changes in neurodevelopmental disorders.

TRC051384, an Hsf1 activator, protects spiral ganglion neurons from noise-induced hearing loss by restoring proteasome function and preserving synapse density.

The paper investigates how specific subiculum-to-retrosplenial cortex projections contribute to trace fear conditioning by analyzing their activity patterns during memory formation and recall.

This study identifies RAD23A and USP13 as modifier genes that enhance TDP-43 solubility and reduce neuronal toxicity in ALS models.

The paper investigates the functional role of recursive splicing in CADM2, showing that its deletion leads to altered gene expression and behavioral changes in neurodevelopmental disorders.

This study shows that reducing RAD23A in TDP-43 mice improves survival, behavior, and reduces TDP-43 pathology and transcriptomic alterations.

SynBot is an open-source software for automated synapse quantification from light microscopy images, improving speed, reproducibility, and ease of use.

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

This study investigates a missense mutation in the GRIK2 gene, showing it disrupts SK channel function, leading to increased dendritic excitability and synaptic integration in hippocampal neurons.

The paper identifies neuron-type-specific synaptic protein isoform expression in striatal spiny projection neurons and shows its impact on synapse diversity and dysfunction.

This study identifies PRRT2 as a key hub in an epilepsy network disrupted by 16p11.2 duplication and shows its correction rescues multiple neuropsychiatric and seizure-related phenotypes in mice.

The paper develops DELTA, a method to measure brain-wide synaptic protein turnover at single-synapse resolution, revealing localized plasticity in hippocampal CA1 during learning.

The paper investigates how noise exposure alters the cochlear proteome in mice, identifying proteostasis responses and proteins involved in regeneration and mitochondrial dysfunction in noise-induced hearing loss.

The paper identifies proteome-wide changes in mouse models of Alzheimer's disease, highlighting ApoE dysregulation and synaptic protein loss.