Calcineurin B-mediated Ca2+ sensing translates stress signal intensity into the assembly of phase-separated condensates at PERK complexes.
Sebastián M Bairo, Macarena Fernandez, Gonzalo Quassollo, Andrea Pellegrini, Juan Carlos De Battista, Santiago Asis, Mauricio G. Martín, Deborah M. Holstein, James Donald Lechleiter, Gabriela E. Gómez, Mariano Bisbal, Mariana Bollo
The paper identifies CNB as a Ca2+ sensor that links translocon-generated Ca2+ signals to PERK activation through phase-separated condensates.
bioRxiv · Aug 4, 2026 · PreprintCell Biology