Deborah M. Holstein

This study shows that soluble pathogenic tau aggregates are transmitted to astrocytes, causing mitochondrial dysfunction, senescence, and neurovascular uncoupling in a tauopathy model.

The paper identifies CNB as a Ca2+ sensor that links translocon-generated Ca2+ signals to PERK activation through phase-separated condensates.

This study shows that β-hydroxybutyrate reduces brain metabolic stress and infarct size in a mouse stroke model under hyperglycemic conditions.

This study shows AST-004, an A1R/A3R agonist, reduces brain infarction in mouse and rat stroke models, with efficacy dependent on A3R signaling and astrocyte mitochondrial metabolism.