Mariano Bisbal

BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons

The paper uses imaging to study the spatial distribution of betaII-spectrin in human motor neuron axons, revealing a gap-and-patch pattern in the actin/spectrin membrane skeleton.

Calcineurin B-mediated Ca2+ sensing translates stress signal intensity into the assembly of phase-separated condensates at PERK complexes.

The paper identifies CNB as a Ca2+ sensor that links translocon-generated Ca2+ signals to PERK activation through phase-separated condensates.

GM1-oligosaccharide rescues rotenone-impaired neuronal polarization through RhoA/ROCK modulation and mitochondrial protection

This study shows that osGM1 rescues rotenone-induced neuronal polarization defects by modulating RhoA/ROCK and protecting mitochondria.

Nanoscale organization of betaII-spectrin within segments of the membrane-associated periodic skeleton in mouse sciatic nerve axons

This study uses super-resolution microscopy to reveal the nanoscale organization of betaII-spectrin in mouse sciatic nerve axons, showing discrete clusters with specific spacing and density.

Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways

This study shows RhoA signaling has both inhibitory and stimulatory effects on axon development depending on timing, location, and downstream effectors.