Neuronal CBP-1 is required for enhanced body muscle proteostasis in response to reduced translation downstream of mTOR
Santina Snow, Dilawar Ahmad Mir, Zhengxin Ma, Jordan Horrocks, Matthew Cox, Marissa N. Ruzga, Hussein Sayed, Aric N. Rogers
This study shows that reducing translation in neurons or germline in C. elegans enhances muscle proteostasis and resilience to stress by increasing heat shock gene expression and muscle regulatory gene expression.
Frontiers in Bioscience-Landmark · Jul 23, 2024Peer-reviewedGenetics