Pankaj Kapahi

Methylglyoxal-induced glycation stress promotes aortic stiffening: Putative mechanistic roles of oxidative stress and cellular senescence

This study shows that methylglyoxal-induced glycation stress causes aortic stiffening through oxidative stress and cellular senescence, and a glycation-lowering compound mitigates these effects.

Growth Hormone Excess Drives Liver Aging via increased Glycation stress

This study shows that growth hormone excess in mice causes liver aging by increasing glycation stress, which can be reversed with glycation-lowering compounds.

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

This study shows that doxorubicin chemotherapy induces aortic stiffening via cellular senescence and the senescence-associated secretory phenotype, which can be mitigated by senolytic therapy.

Inhibition of the metalloprotease ADAM19 as a Novel Senomorphic Strategy to Ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)

This study identifies ADAM19 as a modulator of the senescence-associated secretory phenotype (SASP) and shows that its inhibition reduces gut permeability and senescence markers in multiple species.

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humans.

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

This study identifies MG-H1 as a mediator of increased food intake in C. elegans glod-4 mutants through a tyramine signaling pathway regulated by the GATA transcription factor ELT-3.

Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

This paper develops a retinal aging clock from fundus images to predict chronological age and identifies genetic variants associated with accelerated aging.

miR-125-chinmo pathway regulates dietary restriction dependent enhancement of lifespan in Drosophila

This study identifies miR-125 and its target chinmo as regulators of dietary restriction-induced lifespan extension in Drosophila, highlighting their role in fat metabolism and longevity.

Dietary restriction and clock delay eye aging to extend lifespan in D. melanogaster

This study shows dietary restriction extends lifespan in D. melanogaster by protecting the visual system from age and light-related damage through circadian regulation.

Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal homeostasis and survival in Drosophila

This study identifies Musashi as a regulator of intestinal stem cell function in Drosophila, showing its role in improving survival and gut permeability after radiation exposure.

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan in D. melanogaster

The paper identifies genetic mechanisms underlying diet-dependent lifespan and healthspan in D. melanogaster using GWAS and validates gene effects on lifespan and climbing ability.

Translational regulation of non-autonomous mitochondrial stress response promotes longevity

The paper identifies translational repression of CYC-2.1 in the germline as a mechanism that extends lifespan through non-autonomous activation of UPRmt and AMPK in C. elegans.

Dietary restriction induces post-transcriptional regulation of longevity genes.

This study identifies post-transcriptional mechanisms regulating longevity in C. elegans under dietary restriction, highlighting roles for RNA binding proteins, microRNA, and nonsense mediated decay.

RiboTag translatomic profiling of Drosophila oenocytes under aging and oxidative stress

This study uses RiboTag sequencing to analyze the translatome of Drosophila oenocytes under aging and oxidative stress, identifying shared molecular mechanisms with mammalian liver aging.