Author

Sara Monteiro Lopes

Centro de Neurociências e Biologia Celular

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Ana Rita Fernandes· 1 shared Ana Vasconcelos‐FerreiraiD· 1 shared Carlos A. MatosiD· 1 shared Clévio NóbregaiD· 1 shared Daniela Camargo de OliveiraiD· 1 shared Dina PereiraiD· 1 shared F. Ann Ran· 1 shared Feng ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Ana Rita Fernandes

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1 paper

Recent·Most cited

Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity

Sara Monteiro Lopes, Miguel Monteiro Lopes, Daniela Camargo de Oliveira, Magda M. Santana, Ana Rita Fernandes, Ana Vasconcelos‐Ferreira, Dina Pereira, Maria Casquinha, Clévio Nóbrega, Carlos A. Matos, Neville E. Sanjana, Patrick D. Hsu, F. Ann Ran, Lukasz J. Swiech, Le Cong, , Luís Pereira de Almeida

This study compares CRISPR-Cas9 and TALEN gene editing in a mouse model of Machado-Joseph disease, showing CRISPR-Cas9 reduces ATXN3 aggregates and delays disease progression.

bioRxiv · Feb 14, 2025 · PreprintNeuroscience