Author

Lukasz J. Swiech

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Feng ZhangiD· 2 shared Ana Rita Fernandes· 1 shared Ana Vasconcelos‐FerreiraiD· 1 shared Benjamin E. DevermaniD· 1 shared Carlos A. MatosiD· 1 shared Clévio NóbregaiD· 1 shared Daniela Camargo de OliveiraiD· 1 shared Dina PereiraiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Feng ZhangORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 14, 2025

Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity

Sara Monteiro Lopes, Miguel Monteiro Lopes, Daniela Camargo de Oliveira…·Luís Pereira de Almeida

This study compares CRISPR-Cas9 and TALEN gene editing in a mouse model of Machado-Joseph disease, showing CRISPR-Cas9 reduces ATXN3 aggregates and delays disease progression.

DOI 10.1101/2025.02.14.637261

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 28, 2023

Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer.

Fernando J. Bustos, Swarna Pandian, Henny Haensgen…·Martha Constantine‐Paton

This study removes a genomic duplication in a mouse model using DN-CRISPRs, improving synaptic transmission and behavior.

2 citations

mouseexperimental assay

𝕏 PostBluesky