Super-enhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer
Osama Hidmi, Diala Shatleh, Sara Oster Flayshman, Jonathan Monin, Rami I. Aqeilan
This study shows that super-enhancer activity influences transcription stress and DNA break repair dynamics in cancer, with γH2AX marking linked to DSB turnover and mutagenic vulnerability.
Science Advances · Jan 21, 2026Peer-reviewedMolecular Biology