Author

Sarah A. Barnes

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

David H. BechhoferiD· 2 shared Michael B. LazarusiD· 2 shared Afrooz Golestanian· 1 shared Alisha N. JonesiD· 1 shared Carisse LansiquotiD· 1 shared Harsha VenkateshiD· 1 shared Olga RechkoblitiD· 1 shared Ruoxi WuiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

David H. BechhoferORCID

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2 papers

Recent·Most cited

Structural and biophysical insights into the unique RNase YicC

Ruoxi Wu, Harsha Venkatesh, Carisse Lansiquot, Sarah A. Barnes, Afrooz Golestanian, Olga Rechkoblit, Alisha N. Jones, David H. Bechhofer, Michael B. Lazarus

This study reveals the structural and biophysical mechanisms of YicC, a novel bacterial RNase, showing its RNA binding and cleavage mechanism involving Mg2+ ions and dimeric conformations.

bioRxiv · Sep 17, 2026 · PreprintBiochemistry

Cleavage specificity of E. coli YicC endoribonuclease

Sarah A. Barnes, Michael B. Lazarus, David H. Bechhofer

The paper investigates the cleavage specificity of E. coli YicC endoribonuclease using oligonucleotide substrates, finding that small, structured RNAs are preferred substrates.

RNA · Jun 15, 2026Peer-reviewedMolecular Biology