Author

Ruoxi Wu

Icahn School of Medicine at Mount SinaiORCID 0000-0002-3136-3280Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Carisse LansiquotiD· 2 shared Michael B. LazarusiD· 2 shared Afrooz Golestanian· 1 shared Alisha N. JonesiD· 1 shared David H. BechhoferiD· 1 shared H. Ümit KanıskaniD· 1 shared Harsha VenkateshiD· 1 shared Jian JiniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Carisse LansiquotORCID

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2 papers

Recent·Most cited

Structural and biophysical insights into the unique RNase YicC

Ruoxi Wu, Harsha Venkatesh, Carisse Lansiquot, Sarah A. Barnes, Afrooz Golestanian, Olga Rechkoblit, Alisha N. Jones, David H. Bechhofer, Michael B. Lazarus

This study reveals the structural and biophysical mechanisms of YicC, a novel bacterial RNase, showing its RNA binding and cleavage mechanism involving Mg2+ ions and dimeric conformations.

bioRxiv · Sep 17, 2026 · PreprintBiochemistry

Structural and biochemical characterization of a novel inhibitor of NMNAT1, the gatekeeper of nuclear NAD+ biosynthesis

Carisse Lansiquot, Ruoxi Wu, Joanna P. Davies, Xiangyang Song, H. Ümit Kanıskan, Jian Jin, Michael B. Lazarus

The paper identifies AMI-1 as an inhibitor of NMNAT1, shows its effect on NAD+ levels and cancer cell viability, and determines its binding mechanism via cryo-EM.

bioRxiv · Apr 8, 2026 · PreprintBiochemistry