Author

David H. Bechhofer

Icahn School of Medicine at Mount SinaiORCID 0000-0002-8502-2430Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Michael B. LazarusiD· 2 shared Sarah A. Barnes· 2 shared Afrooz Golestanian· 1 shared Alisha N. JonesiD· 1 shared Carisse LansiquotiD· 1 shared Harsha VenkateshiD· 1 shared Olga RechkoblitiD· 1 shared Ruoxi WuiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

Michael B. LazarusORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 17, 2026

Structural and biophysical insights into the unique RNase YicC

Ruoxi Wu, Harsha Venkatesh, Carisse Lansiquot…·Michael B. Lazarus

This study reveals the structural and biophysical mechanisms of YicC, a novel bacterial RNase, showing its RNA binding and cleavage mechanism involving Mg2+ ions and dimeric conformations.

DOI 10.64898/2026.09.15.751841

bacteria (other)protein structure

𝕏 PostBluesky

Molecular BiologyRNAPeer-reviewedJun 15, 2026

Cleavage specificity of E. coli YicC endoribonuclease

Sarah A. Barnes, Michael B. Lazarus, David H. Bechhofer

The paper investigates the cleavage specificity of E. coli YicC endoribonuclease using oligonucleotide substrates, finding that small, structured RNAs are preferred substrates.

DOI 10.1261/rna.081057.126

E. coliexperimental assay

𝕏 PostBluesky