Human RIG-I deficiency confers susceptibility to Kaposi Sarcoma via loss of latency control
Lucie Roussel, Stéphane Bernier, Mélanie J. Langelier, Yichun Sun, Irem Ulku, Benjamin Mak, Yongbiao Li, Anna Perez, Alexi Wloski, Isabelle Angers, Lily-Rose Vinh, Annie Beauchamp, Sarah Boissel, A. Kevin Watters, Simon Rousseau, , Donald Cuong Vinh
This study identifies RIG-I deficiency as a cause of classic Kaposi sarcoma by impairing control of KSHV infection and reactivation.
bioRxiv · Sep 19, 2025 · PreprintImmunology