Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
Donal Skelly, Éadaoin W. Griffin, Carol Murray, Sarah C. Harney, Conor O’Boyle, Edel Hennessy, Marc‐André Dansereau, Arshed Nazmi, Lucas Silva Tortorelli, J. N. P. Rawlins, David M. Bannerman, Colm M. Cunningham
This study shows that systemic inflammation causes acute cognitive dysfunction and brain injury through separate IL-1-dependent mechanisms, with implications for managing cognitive decline during illness.
Molecular Psychiatry · Jun 6, 2018Peer-reviewedNeuroscience