Pathway-wide base editing charts chemical-genetic interactions in MAPK signaling
James Woods, Calvin Xiao Yang Hu, Dong Man Jang, Camille Freedman, Sarah Canarelli, Hui Si Kwok, Irtiza Iram, Michael J. Eck, Brian B. Liau
This paper uses CRISPR base editing to map chemical-genetic interactions in the MAPK pathway, revealing drug resistance mechanisms and functional hotspots.
bioRxiv · Sep 28, 2026 · PreprintCancer Biology