Author

Irtiza Iram

Broad InstituteORCID 0009-0009-4037-5054Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Brian B. LiauiD· 2 shared Hui Si KwokiD· 2 shared Amanda L. WaterburyiD· 1 shared Andrea MatteviiD· 1 shared Calvin Xiao Yang Hu· 1 shared Camille Freedman· 1 shared Ceejay LeeiD· 1 shared Dong Man JangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Brian B. LiauORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 28, 2026

Pathway-wide base editing charts chemical-genetic interactions in MAPK signaling

James Woods, Calvin Xiao Yang Hu, Dong Man Jang…·Brian B. Liau

This paper uses CRISPR base editing to map chemical-genetic interactions in the MAPK pathway, revealing drug resistance mechanisms and functional hotspots.

DOI 10.64898/2026.09.25.753639

humanexperimental assay

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Molecular BiologyNaturePeer-reviewedFeb 12, 2025

Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes

Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie…·Ning Zheng

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

59 citationstop 1%

humanproteomics

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