Dong Man Jang

This paper uses CRISPR base editing to map chemical-genetic interactions in the MAPK pathway, revealing drug resistance mechanisms and functional hotspots.

The paper investigates MEK inhibitor selectivity across RAF isoforms and develops a covalent ARAF-MEK inhibitor with improved potency.

This study shows that RAF inhibitors paradoxically activate ARAF, BRAF, and CRAF through dimerization, not negative allostery, by using biochemical assays and mass photometry.

This study compares the potency of thirteen RAF inhibitors against ARAF, BRAF, and CRAF isoforms, revealing differences in inhibitor selectivity and mechanism.