Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS
Michael E. Bekier, Emile S. Pinarbasi, Gopinath Krishnan, Jack J. Mesojedec, Madelaine Hurley, Harisankar Harikumar Sheela, Catherine A. Collins, Layla Ghaffari, Martina de Majo, Erik M. Ullian, Mark Koontz, Sarah Coleman, Xingli Li, Elizabeth M.H. Tank, Jacob Waksmacki, , Sami J. Barmada
This study shows NLK disrupts nuclear import, causing TDP43 mislocalization in ALS, and suggests NLK as a therapeutic target.
Journal of Clinical Investigation · Jun 24, 2025Peer-reviewedNeuroscience