Erik M. Ullian

The paper introduces Plexus, a self-supervised model for capturing neuronal activity dynamics, and demonstrates its effectiveness in identifying genetic modifiers of neuronal activity in frontotemporal dementia.

This paper develops a method to rapidly generate ventral A9-like dopaminergic neurons from iPSCs using small molecules and Ascl1 expression, creating functional 3D organoids for Parkinson's disease research.

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

This study shows NLK disrupts nuclear import, causing TDP43 mislocalization in ALS, and suggests NLK as a therapeutic target.

The paper develops iAssembloids to study neuron-glia interactions using CRISPRi screens and finds GSK3β inhibits NRF2-mediated oxidative stress response and APOE-4 promotes neuronal activity.

The paper identifies C12ORF57 as a key regulator of synaptic AMPA currents and excitatory neuronal homeostasis, showing its role in synaptic homeostatic downscaling and its disruption in Temtamy syndrome.

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

The paper shows that loss of GRN in human brain organoids leads to TDP-43 pathology, driven by astrocytes, and can be rescued by progranulin.

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

The paper maps astrocyte layer diversity in the cortex using a high-content spatial transcriptomic pipeline, revealing distinct astrocyte identities and their relationship to neuronal organization.