The paper shows that Wnd/DLK signaling in Drosophila motoneurons is activated only when synaptic terminals are completely removed, not when they are partially spared.

eLife · Oct 29, 2025Peer-reviewedNeuroscience

Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.

Ligia B. Schmitd, Hannah Hafner, Ayobami L. Ward, Elham Asghari Adib, Natália P. Biscola, Rafi Kohen, Mitre Athaiya, Meghan Tuttle, Manav Patel, Rachel E. Williamson, Emily Desai, Julianna Bennett, Grace Saxman, David Wilborn, Jaisha Shumpert, , Roman J. Giger

Science Translational Medicine · Oct 8, 2025Peer-reviewedNeuroscience

Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS

Michael E. Bekier, Emile S. Pinarbasi, Gopinath Krishnan, Jack J. Mesojedec, Madelaine Hurley, Harisankar Harikumar Sheela, Catherine A. Collins, Layla Ghaffari, Martina de Majo, Erik M. Ullian, Mark Koontz, Sarah Coleman, Xingli Li, Elizabeth M.H. Tank, Jacob Waksmacki, , Sami J. Barmada

This study shows NLK disrupts nuclear import, causing TDP43 mislocalization in ALS, and suggests NLK as a therapeutic target.

Journal of Clinical Investigation · Jun 24, 2025Peer-reviewedNeuroscience

Pyruvate kinase deficiency links metabolic perturbations to neurodegeneration and axonal protection

Thomas J. Waller, Catherine A. Collins, Monica Dus

This study shows that pyruvate kinase deficiency causes axonal and synaptic degeneration in Drosophila, linking metabolic changes to neurodegeneration and axonal protection through specific signaling pathways.

Molecular Metabolism · Jun 10, 2025Peer-reviewedNeuroscience