Author

Sarah Holec

Max Planck Institute of Immunobiology and Epigenetics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:multiome· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Carlos Alfonso-GonzaleziD· 2 shared Fernando Mateos· 2 shared Judit CarrascoiD· 2 shared Mengjin Shi· 2 shared Sakshi Gorey· 2 shared Valérie HilgersiD· 2 shared Alejandro Gomez‐AuliiD· 1 shared Anton HeßiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Carlos Alfonso-GonzalezORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Regulation of protein abundance in neurons by selective translation of 3'UTR isoforms

Sakshi Gorey, Hasan Can Ozbulut, Judit Carrasco, Ying Zhang, Anton Heß, Ipek Akol, Carlos Alfonso-Gonzalez, Mengjin Shi, Dominika Grzejda, Julian Wolter-Mess, Mirijam Egg, Fernando Mateos, Sarah Holec, Alejandro Gomez‐Auli, Nina Cabezas‐Wallscheid, , Valérie Hilgers

The paper shows that long 3'UTR isoforms in neurons are less efficiently translated than short ones, mediated by ELAV and Pumilio, and that disrupting this mechanism reduces viability and stress resilience.

bioRxiv · Jul 9, 2026 · PreprintMolecular Biology

ELAV mediates circular RNA biogenesis in neurons

Carlos Alfonso-Gonzalez, Mengjin Shi, Sakshi Gorey, Sarah Holec, Judit Carrasco, Michael Rauer, Stylianos Tsagkris, Fernando Mateos, Valérie Hilgers

This study shows ELAV regulates neuronal circRNA production by modulating splicing to favor circularization over linear splicing.

bioRxiv · Jun 22, 2024Molecular Biology