Carlos Alfonso-Gonzalez

The paper shows that long 3'UTR isoforms in neurons are less efficiently translated than short ones, mediated by ELAV and Pumilio, and that disrupting this mechanism reduces viability and stress resilience.

This study shows Pumilio binds different mRNA 3' UTR isoforms to regulate synaptic protein localization in Drosophila neurons.

This paper introduces CFC-seq and SALA to sequence non-poly(A) RNAs, identifies 39,425 novel transcriptional units, and reveals a genomic code governing enhancer RNA fate based on promoter architecture.

This study shows ELAV regulates neuronal circRNA production by modulating splicing to favor circularization over linear splicing.