Herpes simplex virus infection promotes ALS pathology through ICP0-mediated PML body disruption
Dennis Freisem, Daniel Rombach, Sarah J. Brockmann, Anne Fink, Zoé Engels, Aurora De Luna, Dhiraj Acharya, Helene Hoenigsperger, Alicia Goreth, Sinje Tigges, Isabel Hagmann, Michiel van Gent, Fabian Zech, Anna Ponomarenko, Angela Rosenbohm, , Karin M. Danzer
This study shows HSV infection increases ALS risk and promotes TDP-43 pathology through ICP0-mediated disruption of PML bodies.
bioRxiv · Mar 27, 2026 · PreprintNeuroscience