Fabian Zech

Laudanosine restricts Ebola virus entry by targeting TPC2-dependent endolysosomal trafficking

The paper identifies Laudanosine as an inhibitor of TPC2-dependent viral entry, effective against Ebola and related viruses without cytotoxicity.

Herpes simplex virus infection promotes ALS pathology through ICP0-mediated PML body disruption

This study shows HSV infection increases ALS risk and promotes TDP-43 pathology through ICP0-mediated disruption of PML bodies.

SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum 1 Efficacy Against Corona and Influenza Viruses

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

ReaxFF-guided Optimisation of VIRIP-based HIV-1 Entry Inhibitors

This paper optimizes a HIV-1 entry inhibitor peptide using ReaxFF molecular dynamics simulations, reducing its size while maintaining or improving antiviral activity.

Attenuated replication and damaging effects of SARS-CoV-2 Omicron in an intestinal epithelial barrier model

This study compares the effects of SARS-CoV-2 early strains and Omicron variants on intestinal barrier function using a human gut epithelial model, finding Omicron causes less damage.

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

The paper identifies key mutations in SARS-CoV-2 and bat coronaviruses that affect ACE2 receptor usage across different species and shows that vaccinated individuals' sera neutralize bat Sarbecovirus Spike proteins.