Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus
James P. Bauer, Sarah L. Rader, Max E. Joffe, Wooseok Kwon, Juliana Quay, Leann Seanez, Chengwen Zhou, Peter Jeffrey Conn, Alan S. Lewis
This study shows that hyperactivating ventral dentate gyrus mossy cells impairs spatial memory in mice, suggesting intrahippocampal hyperactivity may contribute to schizophrenia-related cognitive deficits.
Biological Psychiatry Global Open Science · May 4, 2021Peer-reviewedNeuroscience