Max E. Joffe

The paper identifies sex-specific transcriptional differences in specific cell types of the human subgenual anterior cingulate cortex and links them to GPCR signaling differences in mice.

This paper validates an oral xylazine self-administration model in mice, showing oral bioavailability and preference for fentanyl over xylazine.

The paper investigates how Mu and Delta opioid receptors modulate inhibitory transmission in the prefrontal cortex through distinct cellular and molecular mechanisms in mice.

This study identifies mGlu1 and mGlu5 receptors as key regulators of sex differences in prefrontal cortex parvalbumin interneuron function and binge drinking behavior.

This study shows that acute ethanol increases excitability of PFC VIP-INs, while chronic drinking reduces it in males but not females, with effects persisting into abstinence in males.

This study shows that hyperactivating ventral dentate gyrus mossy cells impairs spatial memory in mice, suggesting intrahippocampal hyperactivity may contribute to schizophrenia-related cognitive deficits.

The paper investigates sex-specific adaptations in prefrontal cortex interneuron physiology in a mouse model of binge drinking, finding sex differences in synaptic changes.