Alan S. Lewis

Effects of repeated developmental GLP-1R agonist exposure on adult behavior and hippocampal structure in mice

This study examines the effects of developmental GLP-1R agonist exposure on adult behavior and hippocampal structure in mice, finding no significant changes in memory or mossy cell numbers.

Glucagon-like peptide-1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis

This study shows GLP-1R differentially regulates mossy cell activity in the ventral dentate gyrus, potentially affecting learning and memory during satiety states.

Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus

This study shows that hyperactivating ventral dentate gyrus mossy cells impairs spatial memory in mice, suggesting intrahippocampal hyperactivity may contribute to schizophrenia-related cognitive deficits.