Peter Jeffrey Conn

This study investigates the effect of M4 receptor activation in the pedunculopontine nucleus on L-DOPA-induced dyskinesia and motor function in hemiparkinsonian rats.

This study shows that activating M1 muscarinic receptors with VU846 slows murine prion disease progression, reduces neuroinflammation, and preserves synaptic proteins.

This study shows that hyperactivating ventral dentate gyrus mossy cells impairs spatial memory in mice, suggesting intrahippocampal hyperactivity may contribute to schizophrenia-related cognitive deficits.

The paper investigates sex-specific adaptations in prefrontal cortex interneuron physiology in a mouse model of binge drinking, finding sex differences in synaptic changes.

The paper shows that phospholipase D is essential for M1 PAM-induced long-term depression in rodent prefrontal cortex, and biased M1 PAMs that do not activate PLD have distinct effects on cortical plasticity.

This study shows that mGlu5 PAMs increase Akt and GSK3β phosphorylation in rat brain regions, suggesting a potential mechanism for their antipsychotic-like effects.