Author

Sarah Laura Krausz

Semmelweis University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

András TálasiD· 2 shared Ervin WelkeriD· 2 shared Péter István KulcsáriD· 2 shared Zoltán LigetiiD· 2 shared Eszter Tóth· 1 shared Krisztina Huszár· 1 shared Vanessza Laura Végi· 1 shared Zsófia Rakvács· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

András TálasORCID

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2 papers

Recent·Most cited

SuperFi-Cas9 exhibits extremely high fidelity but reduced activity in mammalian cells

Péter István Kulcsár, András Tálas, Zoltán Ligeti, Sarah Laura Krausz, Ervin Welker

This study compares SuperFi-Cas9 to first-generation IFN variants, finding it has high fidelity but reduced activity, and shows improved specificity when paired with ABE8e.

Nature Communications · Nov 11, 2022Peer-reviewedMolecular Biology

Target-matched increased fidelity SpCas9 variants can edit any target without genome-wide off-target effects

Péter István Kulcsár, András Tálas, Zoltán Ligeti, Eszter Tóth, Zsófia Rakvács, Vanessza Laura Végi, Sarah Laura Krausz, Krisztina Huszár, Ervin Welker

The paper develops a set of high-fidelity SpCas9 variants that enable efficient and specific genome editing across all target sites without off-target effects.

bioRxiv · Aug 16, 2022 · PreprintMolecular Biology