Author

Ervin Welker

HUN-REN Szegedi Biológiai KutatóközpontORCID 0000-0001-9874-8794Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

András TálasiD· 2 shared Péter István KulcsáriD· 2 shared Sarah Laura Krausz· 2 shared Zoltán LigetiiD· 2 shared Eszter Tóth· 1 shared Krisztina Huszár· 1 shared Vanessza Laura Végi· 1 shared Zsófia Rakvács· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

András TálasORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedNov 11, 2022

SuperFi-Cas9 exhibits extremely high fidelity but reduced activity in mammalian cells

Péter István Kulcsár, András Tálas, Zoltán Ligeti…·Ervin Welker

This study compares SuperFi-Cas9 to first-generation IFN variants, finding it has high fidelity but reduced activity, and shows improved specificity when paired with ABE8e.

43 citations

humanCRISPR screen

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Molecular BiologybioRxivPreprintAug 16, 2022

Target-matched increased fidelity SpCas9 variants can edit any target without genome-wide off-target effects

Péter István Kulcsár, András Tálas, Zoltán Ligeti…·Ervin Welker

The paper develops a set of high-fidelity SpCas9 variants that enable efficient and specific genome editing across all target sites without off-target effects.

1 citation

experimental assay

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