Author

Péter István Kulcsár

Institute of Molecular Life SciencesORCID 0000-0002-7783-5108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

András TálasiD· 2 shared Ervin WelkeriD· 2 shared Sarah Laura Krausz· 2 shared Zoltán LigetiiD· 2 shared Alessio CremonesiiD· 1 shared Anahita RassiiD· 1 shared Daniel Fabio Carpanese· 1 shared Desirée BöckiD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

András TálasORCID

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3 papers

Recent·Most cited

Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model for Parkinson's disease

Desirée Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Péter István Kulcsár, Simon d‘Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, Tommaso Patriarchi, Gerald Schwank

This study uses base editing to downregulate PTBP1 in neurons of a PD mouse model, rescuing motor symptoms without affecting astrocytes.

eLife · Dec 13, 2024Peer-reviewedNeuroscience

SuperFi-Cas9 exhibits extremely high fidelity but reduced activity in mammalian cells

Péter István Kulcsár, András Tálas, Zoltán Ligeti, Sarah Laura Krausz, Ervin Welker

This study compares SuperFi-Cas9 to first-generation IFN variants, finding it has high fidelity but reduced activity, and shows improved specificity when paired with ABE8e.

Nature Communications · Nov 11, 2022Peer-reviewedMolecular Biology

Target-matched increased fidelity SpCas9 variants can edit any target without genome-wide off-target effects

Péter István Kulcsár, András Tálas, Zoltán Ligeti, Eszter Tóth, Zsófia Rakvács, Vanessza Laura Végi, Sarah Laura Krausz, Krisztina Huszár, Ervin Welker

The paper develops a set of high-fidelity SpCas9 variants that enable efficient and specific genome editing across all target sites without off-target effects.

bioRxiv · Aug 16, 2022 · PreprintMolecular Biology