Engineering Synthetic Cell State Transitions by Harnessing Epigenetic Memory
Oscar A. Campos, Alessandro Migliara, Sarah R Wasinger, Zhe Chen, Zoe L. Grant, Pilar Lopez, Benoit G. Bruneau, Satoshi Toda, Wendell A. Lim, Ricardo Almeida
This paper engineers synthetic epigenetic circuits that induce stable gene expression changes and drive cell state transitions through transient cell-cell interactions.
bioRxiv · Sep 29, 2025 · PreprintSynthetic Biology