Satoshi Toda

The paper shows coupling reaction-diffusion circuits with mechanical regulation improves robustness of self-organized pattern formation in synthetic cell systems.

This paper introduces a stencil-based method to create 2D microtissue co-cultures with spatial precision, demonstrating applications in tumor microenvironment modeling, morphogen gradient studies, and intestinal architecture recreation.

The paper introduces a synNotch-based system to detect surface-bound morphogens and shows sFRP2 enhances Wnt3a signaling by stabilizing its surface-bound form.

This paper engineers synthetic epigenetic circuits that induce stable gene expression changes and drive cell state transitions through transient cell-cell interactions.

The paper identifies a mechanism by which epithelial folding irreversibility is controlled through an elastoplastic transition mediated by mechanosensitive actin bracket formation.