Oncometabolite-driven enhancer hypermethylation promotes a hyporesponsive microglial state in IDH-mutant gliomas
Alice Laurenge, Pietro Pugliese, Sarah Scuderi, Bertrand Mathon, Louisa Drouiche, Quentin Richard, Stéphanie Jouannet, Chaima Benmohamed, Kirill Smirnov, Lea Hanna Doumit Sakr, Yvette Hayat, Nina Pottier, Pauline Marijon, Karim Labrèche, Agustí Alentorn, , Luis Jaime Castro‐Vega
This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.
bioRxiv · Aug 23, 2024 · PreprintCancer Biology