Cancer BiologybioRxivPreprint
Oncometabolite-driven enhancer hypermethylation promotes a hyporesponsive microglial state in IDH-mutant gliomas
Alice Laurenge, Pietro Pugliese, Sarah Scuderi…·Luis Jaime Castro‐Vega
This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.
3 citations