Ahmed Idbaïh

The paper establishes and characterizes IDH-mutant astrocytoma cell lines, revealing NOTCH-regulated plasticity between astrocyte-like and oligodendrocyte-like states.

h5adify harmonizes metadata from single-cell datasets using neuro-symbolic methods and local LLMs, improving integration and reducing batch effects.

This study finds that BRAF V600E mosaicism in healthy skin is common in histiocytosis patients and strongly linked to neurodegeneration.

This study shows nicotinamide induces reversible senescence in glioblastoma cells by reprogramming metabolism and reducing SOX2, with senescent cells retaining tumor-forming ability.

The paper identifies clonal inflammatory microglia as a cause of neurodegeneration in LCH and ECD, showing their association with neuronal loss and suggesting CSF1R inhibitors as a therapeutic option.

This paper introduces OncoMimics, a peptide-based immunotherapy using molecular mimicry between commensal bacterial and tumor antigens to induce cross-reactive T cell responses, showing early clinical success in glioblastoma.

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.

This study develops a deep learning algorithm for analyzing label-free brightfield microscopy images to detect cancer stem-like cell fate, showing improved accuracy and speed compared to other methods.

The paper analyzes AID-related mutations across cancers and finds they are associated with better outcomes in ICI-treated patients and contribute to immunogenic neoepitopes.