GeneticsG3 Genes Genomes GeneticsPeer-reviewed
Distinct regulatory mechanisms by the nuclear Argonautes HRDE-1 and NRDE-3 in the soma of Caenorhabditis elegans.
Hector Mendoza, Eshna Jash, Michael B. Davis…·Györgyi Csankovszki
This study investigates the transcriptional effects of disrupting nuclear RNAi in C. elegans, showing that while X chromosome decondensation occurs, global transcriptional de-repression is not observed, and HRDE-1 and NRDE-3 regulate their targets through distinct mechanisms.
DOI 10.1093/g3journal/jkaf057