Author

Hector Mendoza

University of MichiganORCID 0000-0002-0170-9535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 4 Approach:experimental assay· 4 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Györgyi CsankovszkiiD· 4 shared Eshna JashiD· 3 shared Anati Alyaa AzhariD· 2 shared Zoey M. TaniD· 2 shared Audry I. RakozyiD· 1 shared Bahaar ChawlaiD· 1 shared Christian A. McClear· 1 shared Dalia S. KaufmaniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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4 shared papersGenetics

Györgyi CsankovszkiORCID

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4 papers

Recent·Most cited

Multi-level transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal element sex-1

Eshna Jash, Zoey M. Tan, Audry I. Rakozy, Anati Alyaa Azhar, Hector Mendoza, Julia D’Arca, Györgyi Csankovszki

This study identifies additional roles of the C. elegans sex-1 gene in regulating sex determination and dosage compensation beyond its known repression of xol-1.

Genetics · Apr 29, 2026Peer-reviewedDevelopmental Biology

Condensin IDC has a Functional ATPase That is Required for X-Chromosome Dosage Compensation in C. elegans

Bahaar Chawla, Suchi Jatia, Dillon E Sloan, Joshua Eduful, Hector Mendoza, Christian A. McClear, Jeannine J. Tran, Györgyi Csankovszki

The paper shows that the ATPase function of DPY-27 in C. elegans is essential for dosage compensation by enabling DNA binding, X-chromosome condensation, and H4K20me1 enrichment.

Genetics · Mar 17, 2026Peer-reviewedGenetics

Distinct regulatory mechanisms by the nuclear Argonautes HRDE-1 and NRDE-3 in the soma of Caenorhabditis elegans.

Hector Mendoza, Eshna Jash, Michael B. Davis, Rebecca A. Haines, Sarah VanDiepenbos, Györgyi Csankovszki

This study investigates the transcriptional effects of disrupting nuclear RNAi in C. elegans, showing that while X chromosome decondensation occurs, global transcriptional de-repression is not observed, and HRDE-1 and NRDE-3 regulate their targets through distinct mechanisms.

G3 Genes Genomes Genetics · Mar 15, 2025Peer-reviewedGenetics

XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos

Eshna Jash, Anati Alyaa Azhar, Hector Mendoza, Zoey M. Tan, Halle Nicole Escher, Dalia S. Kaufman, Györgyi Csankovszki

This study shows XOL-1 regulates developmental timing and dosage compensation in C. elegans hermaphrodite embryos by modulating the H3K9 methylation landscape.

bioRxiv · Apr 2, 2024 · PreprintGenetics