Comprehensive Functional Self-Antigen Screening to Assess Cross-Reactivity in a Promiscuous Engineered T-cell Receptor
Govinda Sharma, Fei Teng, James W. Round, Sophie Sneddon, Scott D. Brown, Sarania Sivasothy, Robert A. Holt
The paper uses Tope-seq to identify cross-reactive epitopes in an engineered T-cell receptor that caused off-target toxicity, highlighting the need for comprehensive screening.
bioRxiv · May 13, 2025 · PreprintImmunology