Author

James W. Round

Canada's Michael Smith Genome Sciences CentreORCID 0000-0003-4736-5755Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Robert A. HoltiD· 2 shared Scott D. BrowniD· 2 shared Cody A Despins· 1 shared Fei TengiD· 1 shared Govinda SharmaiD· 1 shared Lisa Dreolini· 1 shared Sarania Sivasothy· 1 shared Sophie SneddoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Robert A. HoltORCID

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2 papers

Recent·Most cited

ImmunologyVaccinesPeer-reviewedJan 12, 2026

Self-multimerization of mRNA LNP-derived antigen improves antibody responses

Cody A Despins, James W. Round, Lisa Dreolini…·Robert A. Holt

This study compares multimerization domains in mRNA LNP vaccines, finding that IMX313 enhances antibody responses more than other domains.

DOI 10.3390/vaccines14010080

mouseprotein structure

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ImmunologybioRxivPreprintMay 13, 2025

Comprehensive Functional Self-Antigen Screening to Assess Cross-Reactivity in a Promiscuous Engineered T-cell Receptor

Govinda Sharma, Fei Teng, James W. Round…·Robert A. Holt

The paper uses Tope-seq to identify cross-reactive epitopes in an engineered T-cell receptor that caused off-target toxicity, highlighting the need for comprehensive screening.

1 citation

humanbulk RNA-seq

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