Route of Adenovirus Type 5-Vectored Influenza Vaccination Shapes Systemic and Mucosal Immunity in a Maternal-Neonatal Pig Model
Stephanie N. Langel, John J Byrne, Diego Feitosa Leal, Abigail Williams, Chaitawat Sirisereewan, Danielle Meritet, Michael C. Rahe, Tatiane Terumi Negrão Watanabe, Sasha Compton, Daniela S. Rajão, Juliana Bonin Ferreira, Sean N. Tucker, Elisa Crisci
This study evaluates the effectiveness of different vaccination routes for a huAd5-vectored influenza vaccine in pregnant pigs, showing that intranasal and intramuscular routes induce stronger maternal immunity and passive transfer to piglets than oral.
bioRxiv · Mar 13, 2026 · PreprintImmunology