Daniela S. Rajão

Impact of Maternal Antibodies and Weaning Stress on the Replication and Transmission of Human H3N2 Influenza A in Piglets

This study examines how maternal antibodies and weaning stress affect piglets' susceptibility to human H3N2 influenza A virus, showing that matched maternal antibodies reduce shedding and transmission while weaning increases viral spread.

Route of Adenovirus Type 5-Vectored Influenza Vaccination Shapes Systemic and Mucosal Immunity in a Maternal-Neonatal Pig Model

This study evaluates the effectiveness of different vaccination routes for a huAd5-vectored influenza vaccine in pregnant pigs, showing that intranasal and intramuscular routes induce stronger maternal immunity and passive transfer to piglets than oral.

Vaccine-induced antigenic drift of a human-origin H3N2 Influenza A virus in swine alters glycan binding and sialic acid avidity

This study shows vaccine-induced immunity drives antigenic drift in a human-origin H3N2 virus in swine, altering HA receptor binding and glycan specificity.

Passage of human-origin influenza A virus in swine tracheal epithelial cells selects for adaptive mutations in the hemagglutinin gene

This study shows that serial passage of a human-origin H3N2 virus in swine tracheal epithelial cells selects for adaptive HA mutations that increase viral fitness in swine cells.

Air-Liquid Interface Model for Influenza Aerosol Exposure In Vitro

This paper develops an in vitro aerosol exposure system to study influenza virus infectivity in different cell types and identifies differences in airborne infectivity among virus strains.

Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential

This study shows that dispersal within the respiratory tract affects viral genetic diversity and evolutionary potential, with nasal and tracheal regions maintaining diversity while lung regions show genetic distinctness.